Middle Drain is a canal located in Hudspeth County, Texas. It appears on the Fort Hancock USGS 7.5-minute topographic quadrangle. The elevation at this location is approximately 3,526.90 feet (1,075.00 m) above sea level. The nearest populated place is Fort Hancock East Unit Number 1 Colonia, approximately 0.8 miles to the NNE.

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